Non-AIDS defining cancers in the D:A:D Study - time trends and predictors of survival: a cohort study
Identifieur interne : 004574 ( Main/Exploration ); précédent : 004573; suivant : 004575Non-AIDS defining cancers in the D:A:D Study - time trends and predictors of survival: a cohort study
Auteurs : Signe W. Worm [Danemark] ; Mark Bower [Royaume-Uni] ; Peter Reiss [Pays-Bas] ; Fabrice Bonnet [France] ; Matthew Law [Australie] ; Gerd F Tkenheuer [Allemagne] ; Antonella D Rminio Monforte [Italie] ; Donald I. Abrams [États-Unis] ; Andrew Grulich [Australie] ; Eric Fontas [France] ; Ole Kirk [Danemark] ; Hansjakob Furrer [Suisse] ; Stephane De Wit [Belgique] ; Andrew Phillips [Royaume-Uni] ; Jens D. Lundgren [Danemark] ; Caroline A. Sabin [Royaume-Uni]Source :
- BMC Infectious Diseases [ 1471-2334 ] ; 2013.
Abstract
Non-AIDS defining cancers (NADC) are an important cause of morbidity and mortality in HIV-positive individuals. Using data from a large international cohort of HIV-positive individuals, we described the incidence of NADC from 2004–2010, and described subsequent mortality and predictors of these.
Individuals were followed from 1st January 2004/enrolment in study, until the earliest of a new NADC, 1st February 2010, death or six months after the patient’s last visit. Incidence rates were estimated for each year of follow-up, overall and stratified by gender, age and mode of HIV acquisition. Cumulative risk of mortality following NADC diagnosis was summarised using Kaplan-Meier methods, with follow-up for these analyses from the date of NADC diagnosis until the patient’s death, 1st February 2010 or 6 months after the patient’s last visit. Factors associated with mortality following NADC diagnosis were identified using multivariable Cox proportional hazards regression.
Over 176,775 person-years (PY), 880 (2.1%) patients developed a new NADC (incidence: 4.98/1000PY [95% confidence interval 4.65, 5.31]). Over a third of these patients (327, 37.2%) had died by 1st February 2010. Time trends for lung cancer, anal cancer and Hodgkin’s lymphoma were broadly consistent. Kaplan-Meier cumulative mortality estimates at 1, 3 and 5 years after NADC diagnosis were 28.2% [95% CI 25.1-31.2], 42.0% [38.2-45.8] and 47.3% [42.4-52.2], respectively. Significant predictors of poorer survival after diagnosis of NADC were lung cancer (compared to other cancer types), male gender, non-white ethnicity, and smoking status. Later year of diagnosis and higher CD4 count at NADC diagnosis were associated with improved survival. The incidence of NADC remained stable over the period 2004–2010 in this large observational cohort.
The prognosis after diagnosis of NADC, in particular lung cancer and disseminated cancer, is poor but has improved somewhat over time. Modifiable risk factors, such as smoking and low CD4 counts, were associated with mortality following a diagnosis of NADC.
Url:
DOI: 10.1186/1471-2334-13-471
PubMed: 24106926
PubMed Central: 3852673
Affiliations:
- Allemagne, Australie, Belgique, Danemark, France, Italie, Pays-Bas, Royaume-Uni, Suisse, États-Unis
- Angleterre, Aquitaine, Californie, Canton de Berne, Grand Londres, Hollande-Septentrionale, Hovedstaden, Lombardie, Nouvelle-Aquitaine, Nouvelle-Galles du Sud, Provence-Alpes-Côte d'Azur, Région de Bruxelles-Capitale
- Amsterdam, Berne, Bordeaux, Bruxelles, Copenhague, Londres, Milan, Nice, San Francisco, Sydney
- University College de Londres
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 001598
- to stream Pmc, to step Curation: 001458
- to stream Pmc, to step Checkpoint: 001979
- to stream Ncbi, to step Merge: 001508
- to stream Ncbi, to step Curation: 001508
- to stream Ncbi, to step Checkpoint: 001508
- to stream Main, to step Merge: 004672
- to stream Main, to step Curation: 004574
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Non-AIDS defining cancers in the D:A:D Study - time trends and predictors of survival: a cohort study</title>
<author><name sortKey="Worm, Signe W" sort="Worm, Signe W" uniqKey="Worm S" first="Signe W" last="Worm">Signe W. Worm</name>
<affiliation wicri:level="3"><nlm:aff id="I1">Copenhagen HIV Programme, University of Copenhagen, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Copenhagen HIV Programme, University of Copenhagen, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bower, Mark" sort="Bower, Mark" uniqKey="Bower M" first="Mark" last="Bower">Mark Bower</name>
<affiliation wicri:level="3"><nlm:aff id="I2">Chelsea and Westminster Hospital, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Chelsea and Westminster Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Reiss, Peter" sort="Reiss, Peter" uniqKey="Reiss P" first="Peter" last="Reiss">Peter Reiss</name>
<affiliation wicri:level="3"><nlm:aff id="I3">Academic Medical Center, Amsterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Academic Medical Center, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bonnet, Fabrice" sort="Bonnet, Fabrice" uniqKey="Bonnet F" first="Fabrice" last="Bonnet">Fabrice Bonnet</name>
<affiliation wicri:level="3"><nlm:aff id="I4">ISPED, Universite Victor Segalen, Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>ISPED, Universite Victor Segalen, Bordeaux</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Law, Matthew" sort="Law, Matthew" uniqKey="Law M" first="Matthew" last="Law">Matthew Law</name>
<affiliation wicri:level="3"><nlm:aff id="I5">Kirby Institute, University of New South Wales, Sydney, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Kirby Institute, University of New South Wales, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="F Tkenheuer, Gerd" sort="F Tkenheuer, Gerd" uniqKey="F Tkenheuer G" first="Gerd" last="F Tkenheuer">Gerd F Tkenheuer</name>
<affiliation wicri:level="1"><nlm:aff id="I6">University Hospital of Cologne, Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>University Hospital of Cologne, Cologne</wicri:regionArea>
<wicri:noRegion>Cologne</wicri:noRegion>
<wicri:noRegion>Cologne</wicri:noRegion>
<wicri:noRegion>Cologne</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="D Rminio Monforte, Antonella" sort="D Rminio Monforte, Antonella" uniqKey="D Rminio Monforte A" first="Antonella" last="D Rminio Monforte">Antonella D Rminio Monforte</name>
<affiliation wicri:level="3"><nlm:aff id="I7">Hospital San Paolo, University of Milan, Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Hospital San Paolo, University of Milan, Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Abrams, Donald I" sort="Abrams, Donald I" uniqKey="Abrams D" first="Donald I" last="Abrams">Donald I. Abrams</name>
<affiliation wicri:level="3"><nlm:aff id="I8">Hematology-Oncology, San Francisco General Hospital/University of California, San Francisco, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Hematology-Oncology, San Francisco General Hospital/University of California, San Francisco</wicri:regionArea>
<placeName><settlement type="city">San Francisco</settlement>
<region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Grulich, Andrew" sort="Grulich, Andrew" uniqKey="Grulich A" first="Andrew" last="Grulich">Andrew Grulich</name>
<affiliation wicri:level="3"><nlm:aff id="I5">Kirby Institute, University of New South Wales, Sydney, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Kirby Institute, University of New South Wales, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fontas, Eric" sort="Fontas, Eric" uniqKey="Fontas E" first="Eric" last="Fontas">Eric Fontas</name>
<affiliation wicri:level="3"><nlm:aff id="I9">CHU Nice Hopital de l’Archet, Nice, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>CHU Nice Hopital de l’Archet, Nice</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Nice</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kirk, Ole" sort="Kirk, Ole" uniqKey="Kirk O" first="Ole" last="Kirk">Ole Kirk</name>
<affiliation wicri:level="3"><nlm:aff id="I1">Copenhagen HIV Programme, University of Copenhagen, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Copenhagen HIV Programme, University of Copenhagen, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Furrer, Hansjakob" sort="Furrer, Hansjakob" uniqKey="Furrer H" first="Hansjakob" last="Furrer">Hansjakob Furrer</name>
<affiliation wicri:level="3"><nlm:aff id="I10">Department of Infectious Diseases, Bern University Hospital and University of Bern, Bern, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Department of Infectious Diseases, Bern University Hospital and University of Bern, Bern</wicri:regionArea>
<placeName><settlement type="city">Berne</settlement>
<region type="région" nuts="3">Canton de Berne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wit, Stephane De" sort="Wit, Stephane De" uniqKey="Wit S" first="Stephane De" last="Wit">Stephane De Wit</name>
<affiliation wicri:level="3"><nlm:aff id="I11">Department of Infectious Diseases, CHU Saint-Pierre Hospital, Bruxelles, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Infectious Diseases, CHU Saint-Pierre Hospital, Bruxelles</wicri:regionArea>
<placeName><settlement type="city">Bruxelles</settlement>
<region nuts="2">Région de Bruxelles-Capitale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Phillips, Andrew" sort="Phillips, Andrew" uniqKey="Phillips A" first="Andrew" last="Phillips">Andrew Phillips</name>
<affiliation wicri:level="4"><nlm:aff id="I12">Research Department of Infection and Population Health, University College London, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Research Department of Infection and Population Health, University College London, Royal Free Campus, Rowland Hill Street, London NW3 2PF</wicri:regionArea>
<orgName type="university">University College de Londres</orgName>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lundgren, Jens D" sort="Lundgren, Jens D" uniqKey="Lundgren J" first="Jens D" last="Lundgren">Jens D. Lundgren</name>
<affiliation wicri:level="3"><nlm:aff id="I1">Copenhagen HIV Programme, University of Copenhagen, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Copenhagen HIV Programme, University of Copenhagen, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sabin, Caroline A" sort="Sabin, Caroline A" uniqKey="Sabin C" first="Caroline A" last="Sabin">Caroline A. Sabin</name>
<affiliation wicri:level="4"><nlm:aff id="I12">Research Department of Infection and Population Health, University College London, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Research Department of Infection and Population Health, University College London, Royal Free Campus, Rowland Hill Street, London NW3 2PF</wicri:regionArea>
<orgName type="university">University College de Londres</orgName>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">24106926</idno>
<idno type="pmc">3852673</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852673</idno>
<idno type="RBID">PMC:3852673</idno>
<idno type="doi">10.1186/1471-2334-13-471</idno>
<date when="2013">2013</date>
<idno type="wicri:Area/Pmc/Corpus">001598</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001598</idno>
<idno type="wicri:Area/Pmc/Curation">001458</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001458</idno>
<idno type="wicri:Area/Pmc/Checkpoint">001979</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001979</idno>
<idno type="wicri:Area/Ncbi/Merge">001508</idno>
<idno type="wicri:Area/Ncbi/Curation">001508</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001508</idno>
<idno type="wicri:Area/Main/Merge">004672</idno>
<idno type="wicri:Area/Main/Curation">004574</idno>
<idno type="wicri:Area/Main/Exploration">004574</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Non-AIDS defining cancers in the D:A:D Study - time trends and predictors of survival: a cohort study</title>
<author><name sortKey="Worm, Signe W" sort="Worm, Signe W" uniqKey="Worm S" first="Signe W" last="Worm">Signe W. Worm</name>
<affiliation wicri:level="3"><nlm:aff id="I1">Copenhagen HIV Programme, University of Copenhagen, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Copenhagen HIV Programme, University of Copenhagen, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bower, Mark" sort="Bower, Mark" uniqKey="Bower M" first="Mark" last="Bower">Mark Bower</name>
<affiliation wicri:level="3"><nlm:aff id="I2">Chelsea and Westminster Hospital, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Chelsea and Westminster Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Reiss, Peter" sort="Reiss, Peter" uniqKey="Reiss P" first="Peter" last="Reiss">Peter Reiss</name>
<affiliation wicri:level="3"><nlm:aff id="I3">Academic Medical Center, Amsterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Academic Medical Center, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bonnet, Fabrice" sort="Bonnet, Fabrice" uniqKey="Bonnet F" first="Fabrice" last="Bonnet">Fabrice Bonnet</name>
<affiliation wicri:level="3"><nlm:aff id="I4">ISPED, Universite Victor Segalen, Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>ISPED, Universite Victor Segalen, Bordeaux</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Law, Matthew" sort="Law, Matthew" uniqKey="Law M" first="Matthew" last="Law">Matthew Law</name>
<affiliation wicri:level="3"><nlm:aff id="I5">Kirby Institute, University of New South Wales, Sydney, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Kirby Institute, University of New South Wales, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="F Tkenheuer, Gerd" sort="F Tkenheuer, Gerd" uniqKey="F Tkenheuer G" first="Gerd" last="F Tkenheuer">Gerd F Tkenheuer</name>
<affiliation wicri:level="1"><nlm:aff id="I6">University Hospital of Cologne, Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>University Hospital of Cologne, Cologne</wicri:regionArea>
<wicri:noRegion>Cologne</wicri:noRegion>
<wicri:noRegion>Cologne</wicri:noRegion>
<wicri:noRegion>Cologne</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="D Rminio Monforte, Antonella" sort="D Rminio Monforte, Antonella" uniqKey="D Rminio Monforte A" first="Antonella" last="D Rminio Monforte">Antonella D Rminio Monforte</name>
<affiliation wicri:level="3"><nlm:aff id="I7">Hospital San Paolo, University of Milan, Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Hospital San Paolo, University of Milan, Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Abrams, Donald I" sort="Abrams, Donald I" uniqKey="Abrams D" first="Donald I" last="Abrams">Donald I. Abrams</name>
<affiliation wicri:level="3"><nlm:aff id="I8">Hematology-Oncology, San Francisco General Hospital/University of California, San Francisco, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Hematology-Oncology, San Francisco General Hospital/University of California, San Francisco</wicri:regionArea>
<placeName><settlement type="city">San Francisco</settlement>
<region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Grulich, Andrew" sort="Grulich, Andrew" uniqKey="Grulich A" first="Andrew" last="Grulich">Andrew Grulich</name>
<affiliation wicri:level="3"><nlm:aff id="I5">Kirby Institute, University of New South Wales, Sydney, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Kirby Institute, University of New South Wales, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fontas, Eric" sort="Fontas, Eric" uniqKey="Fontas E" first="Eric" last="Fontas">Eric Fontas</name>
<affiliation wicri:level="3"><nlm:aff id="I9">CHU Nice Hopital de l’Archet, Nice, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>CHU Nice Hopital de l’Archet, Nice</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Nice</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kirk, Ole" sort="Kirk, Ole" uniqKey="Kirk O" first="Ole" last="Kirk">Ole Kirk</name>
<affiliation wicri:level="3"><nlm:aff id="I1">Copenhagen HIV Programme, University of Copenhagen, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Copenhagen HIV Programme, University of Copenhagen, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Furrer, Hansjakob" sort="Furrer, Hansjakob" uniqKey="Furrer H" first="Hansjakob" last="Furrer">Hansjakob Furrer</name>
<affiliation wicri:level="3"><nlm:aff id="I10">Department of Infectious Diseases, Bern University Hospital and University of Bern, Bern, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Department of Infectious Diseases, Bern University Hospital and University of Bern, Bern</wicri:regionArea>
<placeName><settlement type="city">Berne</settlement>
<region type="région" nuts="3">Canton de Berne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wit, Stephane De" sort="Wit, Stephane De" uniqKey="Wit S" first="Stephane De" last="Wit">Stephane De Wit</name>
<affiliation wicri:level="3"><nlm:aff id="I11">Department of Infectious Diseases, CHU Saint-Pierre Hospital, Bruxelles, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Infectious Diseases, CHU Saint-Pierre Hospital, Bruxelles</wicri:regionArea>
<placeName><settlement type="city">Bruxelles</settlement>
<region nuts="2">Région de Bruxelles-Capitale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Phillips, Andrew" sort="Phillips, Andrew" uniqKey="Phillips A" first="Andrew" last="Phillips">Andrew Phillips</name>
<affiliation wicri:level="4"><nlm:aff id="I12">Research Department of Infection and Population Health, University College London, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Research Department of Infection and Population Health, University College London, Royal Free Campus, Rowland Hill Street, London NW3 2PF</wicri:regionArea>
<orgName type="university">University College de Londres</orgName>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lundgren, Jens D" sort="Lundgren, Jens D" uniqKey="Lundgren J" first="Jens D" last="Lundgren">Jens D. Lundgren</name>
<affiliation wicri:level="3"><nlm:aff id="I1">Copenhagen HIV Programme, University of Copenhagen, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Copenhagen HIV Programme, University of Copenhagen, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sabin, Caroline A" sort="Sabin, Caroline A" uniqKey="Sabin C" first="Caroline A" last="Sabin">Caroline A. Sabin</name>
<affiliation wicri:level="4"><nlm:aff id="I12">Research Department of Infection and Population Health, University College London, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Research Department of Infection and Population Health, University College London, Royal Free Campus, Rowland Hill Street, London NW3 2PF</wicri:regionArea>
<orgName type="university">University College de Londres</orgName>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">BMC Infectious Diseases</title>
<idno type="eISSN">1471-2334</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Non-AIDS defining cancers (NADC) are an important cause of morbidity and mortality in HIV-positive individuals. Using data from a large international cohort of HIV-positive individuals, we described the incidence of NADC from 2004–2010, and described subsequent mortality and predictors of these.</p>
</sec>
<sec><title>Methods</title>
<p>Individuals were followed from 1st January 2004/enrolment in study, until the earliest of a new NADC, 1st February 2010, death or six months after the patient’s last visit. Incidence rates were estimated for each year of follow-up, overall and stratified by gender, age and mode of HIV acquisition. Cumulative risk of mortality following NADC diagnosis was summarised using Kaplan-Meier methods, with follow-up for these analyses from the date of NADC diagnosis until the patient’s death, 1st February 2010 or 6 months after the patient’s last visit. Factors associated with mortality following NADC diagnosis were identified using multivariable Cox proportional hazards regression.</p>
</sec>
<sec><title>Results</title>
<p>Over 176,775 person-years (PY), 880 (2.1%) patients developed a new NADC (incidence: 4.98/1000PY [95% confidence interval 4.65, 5.31]). Over a third of these patients (327, 37.2%) had died by 1st February 2010. Time trends for lung cancer, anal cancer and Hodgkin’s lymphoma were broadly consistent. Kaplan-Meier cumulative mortality estimates at 1, 3 and 5 years after NADC diagnosis were 28.2% [95% CI 25.1-31.2], 42.0% [38.2-45.8] and 47.3% [42.4-52.2], respectively. Significant predictors of poorer survival after diagnosis of NADC were lung cancer (compared to other cancer types), male gender, non-white ethnicity, and smoking status. Later year of diagnosis and higher CD4 count at NADC diagnosis were associated with improved survival. The incidence of NADC remained stable over the period 2004–2010 in this large observational cohort.</p>
</sec>
<sec><title>Conclusions</title>
<p>The prognosis after diagnosis of NADC, in particular lung cancer and disseminated cancer, is poor but has improved somewhat over time. Modifiable risk factors, such as smoking and low CD4 counts, were associated with mortality following a diagnosis of NADC.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Mocroft, A" uniqKey="Mocroft A">A Mocroft</name>
</author>
<author><name sortKey="Ledergerber, B" uniqKey="Ledergerber B">B Ledergerber</name>
</author>
<author><name sortKey="Katlama, C" uniqKey="Katlama C">C Katlama</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Engels, Ea" uniqKey="Engels E">EA Engels</name>
</author>
<author><name sortKey="Pfeiffer, Rm" uniqKey="Pfeiffer R">RM Pfeiffer</name>
</author>
<author><name sortKey="Goedert, Jj" uniqKey="Goedert J">JJ Goedert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Simard, Ep" uniqKey="Simard E">EP Simard</name>
</author>
<author><name sortKey="Pfeiffer, Rm" uniqKey="Pfeiffer R">RM Pfeiffer</name>
</author>
<author><name sortKey="Engels, Ea" uniqKey="Engels E">EA Engels</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shiels, Ms" uniqKey="Shiels M">MS Shiels</name>
</author>
<author><name sortKey="Pfeiffer, Rm" uniqKey="Pfeiffer R">RM Pfeiffer</name>
</author>
<author><name sortKey="Gail, Mh" uniqKey="Gail M">MH Gail</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Patel, P" uniqKey="Patel P">P Patel</name>
</author>
<author><name sortKey="Hanson, Dl" uniqKey="Hanson D">DL Hanson</name>
</author>
<author><name sortKey="Sullivan, Ps" uniqKey="Sullivan P">PS Sullivan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Powles, T" uniqKey="Powles T">T Powles</name>
</author>
<author><name sortKey="Robinson, D" uniqKey="Robinson D">D Robinson</name>
</author>
<author><name sortKey="Stebbing, J" uniqKey="Stebbing J">J Stebbing</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Franceschi, S" uniqKey="Franceschi S">S Franceschi</name>
</author>
<author><name sortKey="Lise, M" uniqKey="Lise M">M Lise</name>
</author>
<author><name sortKey="Clifford, Gm" uniqKey="Clifford G">GM Clifford</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Long, Jl" uniqKey="Long J">JL Long</name>
</author>
<author><name sortKey="Engels, Ea" uniqKey="Engels E">EA Engels</name>
</author>
<author><name sortKey="Moore, Rd" uniqKey="Moore R">RD Moore</name>
</author>
<author><name sortKey="Gebo, Ka" uniqKey="Gebo K">KA Gebo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hessol, Na" uniqKey="Hessol N">NA Hessol</name>
</author>
<author><name sortKey="Pipkin, S" uniqKey="Pipkin S">S Pipkin</name>
</author>
<author><name sortKey="Schwarcz, S" uniqKey="Schwarcz S">S Schwarcz</name>
</author>
<author><name sortKey="Cress, Rd" uniqKey="Cress R">RD Cress</name>
</author>
<author><name sortKey="Bacchetti, P" uniqKey="Bacchetti P">P Bacchetti</name>
</author>
<author><name sortKey="Scheer, S" uniqKey="Scheer S">S Scheer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Silverberg, Mj" uniqKey="Silverberg M">MJ Silverberg</name>
</author>
<author><name sortKey="Lau, B" uniqKey="Lau B">B Lau</name>
</author>
<author><name sortKey="Justice, Ac" uniqKey="Justice A">AC Justice</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Piketty, C" uniqKey="Piketty C">C Piketty</name>
</author>
<author><name sortKey="Selinger Leneman, H" uniqKey="Selinger Leneman H">H Selinger-Leneman</name>
</author>
<author><name sortKey="Bouvier, Am" uniqKey="Bouvier A">AM Bouvier</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bonnet, F" uniqKey="Bonnet F">F Bonnet</name>
</author>
<author><name sortKey="Burty, C" uniqKey="Burty C">C Burty</name>
</author>
<author><name sortKey="Lewden, C" uniqKey="Lewden C">C Lewden</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Simard, Ep" uniqKey="Simard E">EP Simard</name>
</author>
<author><name sortKey="Engels, Ea" uniqKey="Engels E">EA Engels</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hasse, B" uniqKey="Hasse B">B Hasse</name>
</author>
<author><name sortKey="Ledergerber, B" uniqKey="Ledergerber B">B Ledergerber</name>
</author>
<author><name sortKey="Furrer, H" uniqKey="Furrer H">H Furrer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lowsky, R" uniqKey="Lowsky R">R Lowsky</name>
</author>
<author><name sortKey="Lipton, J" uniqKey="Lipton J">J Lipton</name>
</author>
<author><name sortKey="Fyles, G" uniqKey="Fyles G">G Fyles</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Curtis, Re" uniqKey="Curtis R">RE Curtis</name>
</author>
<author><name sortKey="Rowlings, Pa" uniqKey="Rowlings P">PA Rowlings</name>
</author>
<author><name sortKey="Deeg, Hj" uniqKey="Deeg H">HJ Deeg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tirelli, U" uniqKey="Tirelli U">U Tirelli</name>
</author>
<author><name sortKey="Errante, D" uniqKey="Errante D">D Errante</name>
</author>
<author><name sortKey="Dolcetti, R" uniqKey="Dolcetti R">R Dolcetti</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Biggar, Rj" uniqKey="Biggar R">RJ Biggar</name>
</author>
<author><name sortKey="Engels, Ea" uniqKey="Engels E">EA Engels</name>
</author>
<author><name sortKey="Ly, S" uniqKey="Ly S">S Ly</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Achenbach, Cj" uniqKey="Achenbach C">CJ Achenbach</name>
</author>
<author><name sortKey="Cole, Sr" uniqKey="Cole S">SR Cole</name>
</author>
<author><name sortKey="Kitahata, Mm" uniqKey="Kitahata M">MM Kitahata</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Clifford, Gm" uniqKey="Clifford G">GM Clifford</name>
</author>
<author><name sortKey="Polesel, J" uniqKey="Polesel J">J Polesel</name>
</author>
<author><name sortKey="Rickenbach, M" uniqKey="Rickenbach M">M Rickenbach</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Friis M Ller, N" uniqKey="Friis M Ller N">N Friis-Møller</name>
</author>
<author><name sortKey="Sabin, Ca" uniqKey="Sabin C">CA Sabin</name>
</author>
<author><name sortKey="Weber, R" uniqKey="Weber R">R Weber</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kowalska, Jd" uniqKey="Kowalska J">JD Kowalska</name>
</author>
<author><name sortKey="Friis Moller, N" uniqKey="Friis Moller N">N Friis-Moller</name>
</author>
<author><name sortKey="Kirk, O" uniqKey="Kirk O">O Kirk</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reekie, J" uniqKey="Reekie J">J Reekie</name>
</author>
<author><name sortKey="Kosa, C" uniqKey="Kosa C">C Kosa</name>
</author>
<author><name sortKey="Engsig, F" uniqKey="Engsig F">F Engsig</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Herida, M" uniqKey="Herida M">M Herida</name>
</author>
<author><name sortKey="Mary Krause, M" uniqKey="Mary Krause M">M Mary-Krause</name>
</author>
<author><name sortKey="Kaphan, R" uniqKey="Kaphan R">R Kaphan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Spagnuolo, V" uniqKey="Spagnuolo V">V Spagnuolo</name>
</author>
<author><name sortKey="Galli, L" uniqKey="Galli L">L Galli</name>
</author>
<author><name sortKey="Salpietro, S" uniqKey="Salpietro S">S Salpietro</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Machalek, Da" uniqKey="Machalek D">DA Machalek</name>
</author>
<author><name sortKey="Poynten, M" uniqKey="Poynten M">M Poynten</name>
</author>
<author><name sortKey="Jin, F" uniqKey="Jin F">F Jin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jin, F" uniqKey="Jin F">F Jin</name>
</author>
<author><name sortKey="Stein, An" uniqKey="Stein A">AN Stein</name>
</author>
<author><name sortKey="Conway, El" uniqKey="Conway E">EL Conway</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Grulich, Ae" uniqKey="Grulich A">AE Grulich</name>
</author>
<author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name>
</author>
<author><name sortKey="Mcdonald, A" uniqKey="Mcdonald A">A McDonald</name>
</author>
<author><name sortKey="Correll, Pk" uniqKey="Correll P">PK Correll</name>
</author>
<author><name sortKey="Law, Mg" uniqKey="Law M">MG Law</name>
</author>
<author><name sortKey="Kaldor, Jm" uniqKey="Kaldor J">JM Kaldor</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shiels, Ms" uniqKey="Shiels M">MS Shiels</name>
</author>
<author><name sortKey="Cole, Sr" uniqKey="Cole S">SR Cole</name>
</author>
<author><name sortKey="Mehta, Sh" uniqKey="Mehta S">SH Mehta</name>
</author>
<author><name sortKey="Kirk, Gd" uniqKey="Kirk G">GD Kirk</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hoffmann, C" uniqKey="Hoffmann C">C Hoffmann</name>
</author>
<author><name sortKey="Chow, Ku" uniqKey="Chow K">KU Chow</name>
</author>
<author><name sortKey="Wolf, E" uniqKey="Wolf E">E Wolf</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xicoy, B" uniqKey="Xicoy B">B Xicoy</name>
</author>
<author><name sortKey="Ribera, Jm" uniqKey="Ribera J">JM Ribera</name>
</author>
<author><name sortKey="Miralles, P" uniqKey="Miralles P">P Miralles</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bower, M" uniqKey="Bower M">M Bower</name>
</author>
<author><name sortKey="Powles, T" uniqKey="Powles T">T Powles</name>
</author>
<author><name sortKey="Newsom Davis, T" uniqKey="Newsom Davis T">T Newsom-Davis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Munoz Bongrand, N" uniqKey="Munoz Bongrand N">N Munoz-Bongrand</name>
</author>
<author><name sortKey="Poghosyan, T" uniqKey="Poghosyan T">T Poghosyan</name>
</author>
<author><name sortKey="Zohar, S" uniqKey="Zohar S">S Zohar</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Belgique</li>
<li>Danemark</li>
<li>France</li>
<li>Italie</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>Suisse</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Aquitaine</li>
<li>Californie</li>
<li>Canton de Berne</li>
<li>Grand Londres</li>
<li>Hollande-Septentrionale</li>
<li>Hovedstaden</li>
<li>Lombardie</li>
<li>Nouvelle-Aquitaine</li>
<li>Nouvelle-Galles du Sud</li>
<li>Provence-Alpes-Côte d'Azur</li>
<li>Région de Bruxelles-Capitale</li>
</region>
<settlement><li>Amsterdam</li>
<li>Berne</li>
<li>Bordeaux</li>
<li>Bruxelles</li>
<li>Copenhague</li>
<li>Londres</li>
<li>Milan</li>
<li>Nice</li>
<li>San Francisco</li>
<li>Sydney</li>
</settlement>
<orgName><li>University College de Londres</li>
</orgName>
</list>
<tree><country name="Danemark"><region name="Hovedstaden"><name sortKey="Worm, Signe W" sort="Worm, Signe W" uniqKey="Worm S" first="Signe W" last="Worm">Signe W. Worm</name>
</region>
<name sortKey="Kirk, Ole" sort="Kirk, Ole" uniqKey="Kirk O" first="Ole" last="Kirk">Ole Kirk</name>
<name sortKey="Lundgren, Jens D" sort="Lundgren, Jens D" uniqKey="Lundgren J" first="Jens D" last="Lundgren">Jens D. Lundgren</name>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Bower, Mark" sort="Bower, Mark" uniqKey="Bower M" first="Mark" last="Bower">Mark Bower</name>
</region>
<name sortKey="Phillips, Andrew" sort="Phillips, Andrew" uniqKey="Phillips A" first="Andrew" last="Phillips">Andrew Phillips</name>
<name sortKey="Sabin, Caroline A" sort="Sabin, Caroline A" uniqKey="Sabin C" first="Caroline A" last="Sabin">Caroline A. Sabin</name>
</country>
<country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Reiss, Peter" sort="Reiss, Peter" uniqKey="Reiss P" first="Peter" last="Reiss">Peter Reiss</name>
</region>
</country>
<country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Bonnet, Fabrice" sort="Bonnet, Fabrice" uniqKey="Bonnet F" first="Fabrice" last="Bonnet">Fabrice Bonnet</name>
</region>
<name sortKey="Fontas, Eric" sort="Fontas, Eric" uniqKey="Fontas E" first="Eric" last="Fontas">Eric Fontas</name>
</country>
<country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Law, Matthew" sort="Law, Matthew" uniqKey="Law M" first="Matthew" last="Law">Matthew Law</name>
</region>
<name sortKey="Grulich, Andrew" sort="Grulich, Andrew" uniqKey="Grulich A" first="Andrew" last="Grulich">Andrew Grulich</name>
</country>
<country name="Allemagne"><noRegion><name sortKey="F Tkenheuer, Gerd" sort="F Tkenheuer, Gerd" uniqKey="F Tkenheuer G" first="Gerd" last="F Tkenheuer">Gerd F Tkenheuer</name>
</noRegion>
</country>
<country name="Italie"><region name="Lombardie"><name sortKey="D Rminio Monforte, Antonella" sort="D Rminio Monforte, Antonella" uniqKey="D Rminio Monforte A" first="Antonella" last="D Rminio Monforte">Antonella D Rminio Monforte</name>
</region>
</country>
<country name="États-Unis"><region name="Californie"><name sortKey="Abrams, Donald I" sort="Abrams, Donald I" uniqKey="Abrams D" first="Donald I" last="Abrams">Donald I. Abrams</name>
</region>
</country>
<country name="Suisse"><region name="Canton de Berne"><name sortKey="Furrer, Hansjakob" sort="Furrer, Hansjakob" uniqKey="Furrer H" first="Hansjakob" last="Furrer">Hansjakob Furrer</name>
</region>
</country>
<country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="Wit, Stephane De" sort="Wit, Stephane De" uniqKey="Wit S" first="Stephane De" last="Wit">Stephane De Wit</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004574 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004574 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Asie |area= AustralieFrV1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:3852673 |texte= Non-AIDS defining cancers in the D:A:D Study - time trends and predictors of survival: a cohort study }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:24106926" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a AustralieFrV1
This area was generated with Dilib version V0.6.33. |